BRAM-COR is committed to providing a clear answer to every need of water treatment to produce pharmaceutical waters (i.e. PW or WFI) or compendial water for other critical applications (cosmetics, healthcare, human food and animal feed, for example). Our approach is really focused, with a wide range of specific knowledge. We consider that every pharmaceutical facility needs “pure” water. To meet every specific need it is necessary, in every sense, to go back to the source, analyzing water quality in-situ (the raw water employed), which is very different from place to place.
Then, the task of the pre-treatment of water is just that: bring the particular water to a functional quality, according to the user requirements specification (URS). Techniques such as water softening, descaling, pre filtration, degasification, nanofiltration, electro-deionisation, ozonation, UV treatment and micro-filtration should all be considered, in relation to the feed water quality. Subsequently, the water quality must correspond to the quality levels of the pharmacopoeia required, if it should use, for example, for the production of Water for Injection (infusional bags or bottles, and so on).
Water treatment systems have the task of ensuring a constant quality to the water production, also through physical systems such as reverse osmosis. However, producing WFI with Reverse Osmosis systems requires special attention, since in RO there is not a water changing state (from liquid to vapor, a natural microbiological barrier). We do not think that RO system is the safest method to produce Water for Injection (WFI), unless the feed water is really excellent. Theoretically, above all, with the availability of more technologically advanced membranes, we can get cold WFI with the addition of ultrafiltration. So, the cold WFI meets all the parameters required (USP, EP, JP, …). Our RO Systems + UF achieve an optimal WFI quality; however, once in production, any RO system requires a continuous control on its efficiency, in terms of membrane degradation, biofilm prevention and microbial charges, with periodic sanitization and validation. If there are no obstacles in ensuring this constant monitoring, which must also concern distribution loops, the reverse osmosis system can offer a real and meaningful advantage, reducing the energy needs and thus reducing production costs.
See also the CROS page in this site